Your browser doesn't support javascript.
loading
Preliminary results of a vaginal constraint for reducing G2 late vaginal complications after postoperative brachytherapy in endometrial cancer: a prospective analysis
Zhang, Y; Gomez, G; Ascaso, C; Herreros, A; Fornes, B; Mases, J; Rochera, J; Tagliaferri, L; Sabater, S; Torne, A.
Afiliación
  • Zhang, Y; Henan Provincial People’s Hospital. Zhengzhou. China
  • Gomez, G; Hospital Los Ángeles. Chihuahua. México
  • Ascaso, C; Faculty of Medicine. Fonaments Clínics Dpt. Barcelona. Spain
  • Herreros, A; Hospital Clinic Barcelona. Barcelona. Spain
  • Fornes, B; Hospital Clinic Barcelona. Barcelona. Spain
  • Mases, J; Hospital Clinic Barcelona. Barcelona. Spain
  • Rochera, J; Hospital Clinic Barcelona. Barcelona. Spain
  • Tagliaferri, L; Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Dipartimento di Diagnostica per Immagini. Rome. Italy
  • Sabater, S; Hospital General Universitario de Albacete. Albacete. Spain
  • Torne, A; Hospital Clinic Barcelona. Barcelona. Spain
Clin. transl. oncol. (Print) ; 24(5): 875-881, mayo 2022.
Artículo en Inglés | IBECS | ID: ibc-203789
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
PurposeTo evaluate the preliminary results of the use of 68 Gy EQD2(α/β=3 Gy) as a dose limit to the lowest dose in the most exposed 2 cm3 of the vagina in order to reduce G2 late vaginal problems in postoperative endometrial carcinoma (EC).MethodsFrom November 2016 to October 2019, 69 postoperative EC patients receiving vaginal brachytherapy (VBT) ± external beam radiotherapy (EBRT) were prospectively analyzed. The median EBRT dose was 45 Gy (range 44–50.4 Gy), 1.8−2 Gy/day, 5 fractions(Fr)/week. VBT was administered with the following schedule 1Fr of 7 Gy after EBRT and 2 daily Fr × 7.5 Gy in exclusive VBT. The dose was prescribed at 0.5 cm from the applicator surface with an active length of 2.5 cm; 56 patients were treated with vaginal cylinders (49–3.5 cm, 6–3 cm, and 1–2.5 cm) and 13 with the colpostat technique. The overall VBT dose was adjusted to meet the vaginal restriction of < 68 Gy EQD2(α/β=3 Gy) at 2 cm3. Late toxicity was prospectively assessed using RTOG scores for bladder and rectum, and the objective LENT-SOMA criteria for vagina.ResultsWith a median follow-up of 31.0 months, no vaginal-cuff recurrences were found. Late toxicity only 1G1(1.4%) rectal toxicity; 21G1(30.4%) and 3G2(4.3%) vaginal complications. Only one (1.4%) of 3 G2 manifested as vaginal shortening.ConclusionsIn postoperative EC patients treated with VBT, only one developed G2 vaginal stenosis with the use of 68 Gy EQD2(α/β=3 Gy) as a dose constraint. These preliminary results seem to indicate the value of this dose limit for reducing G2 vaginal stenosis. Nonetheless, these findings should be confirmed in a larger number of patients with longer follow-up.
Asunto(s)


Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Braquiterapia / Neoplasias Endometriales / Constricción Patológica Límite: Humanos Idioma: Inglés Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Artículo Institución/País de afiliación: Faculty of Medicine/Spain / Fondazione Policlinico Universitario Agostino Gemelli IRCCS/Italy / Henan Provincial People’s Hospital/China / Hospital Clinic Barcelona/Spain / Hospital General Universitario de Albacete/Spain / Hospital Los Ángeles/México

Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Braquiterapia / Neoplasias Endometriales / Constricción Patológica Límite: Humanos Idioma: Inglés Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Artículo Institución/País de afiliación: Faculty of Medicine/Spain / Fondazione Policlinico Universitario Agostino Gemelli IRCCS/Italy / Henan Provincial People’s Hospital/China / Hospital Clinic Barcelona/Spain / Hospital General Universitario de Albacete/Spain / Hospital Los Ángeles/México
...