MicroRNA-211-5p as a Biomarker in Early Detection of Uremic Vascular Calcification among Patients with End Stage Renal Disease
Arch. esp. urol. (Ed. impr.)
; 75(8): 714-719, 28 sept. 2022. tab, graf
Article
en En
| IBECS
| ID: ibc-212098
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background: Vascular calcification (VC) is a serious pathological manifestation of vascular terminals and is an important pathological basis of cardiovascular diseases in patients with end-stage renal disease (ESRD). This study explored the clinical value of serum microRNA-211-5p (miR-211-5p) in VC in patients with ESRD, this study was designed. Methods: The relative expression of miR-211-5p in the serum of the calcified group and the non-calcified group was quantified by quantitative reverse transcription polymerase chain reaction. The clinical biochemical indexes and the expression differences in miR-211-5p expression in the serum of groups were compared by two independent samples t-test or nonparametric test or one-way analysis of variance test. The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR-211-5p in patients with ESRD. Results: The relative quantification of serum miR-211-5p was lessened in calcified group and gradually decreased with the progression of VC. Serum miR-211-5p had a high diagnostic accuracy in the diagnosis of VC progression in ESRD patients. Kaplan-Meier and Cox regression methods revealed that miR-211-5p might be an independent biomarker for prognosis of ESRD patients Conclusions: MiR-211-5p is a potential diagnostic and prognostic marker of VC in patients with ESRD (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
MicroARNs
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Calcificación Vascular
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Fallo Renal Crónico
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Arch. esp. urol. (Ed. impr.)
Año:
2022
Tipo del documento:
Article