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Effects of transcranial direct current stimulation on neural activity and functional connectivity during fear extinction
Lee, Dongha; Guiomar, Raquel; Gonçalves, Óscar F; Almeida, Jorge; Ganho-Ávila, Ana.
Afiliación
  • Lee, Dongha; Korea Brain Research Institute. Cognitive Science Research Group. Daegu. Republic of Korea
  • Guiomar, Raquel; University of Coimbra. Faculty of Psychology and Educational Sciences. Center for Research in Neuropsychology and Cognitive Behavioral Intervention. Coimbra. Portugal
  • Gonçalves, Óscar F; University of Coimbra. Faculty of Psychology and Educational Sciences. Center for Research in Neuropsychology and Cognitive Behavioral Intervention. Coimbra. Portugal
  • Almeida, Jorge; University of Coimbra. Faculty of Psychology and Educational Sciences. Center for Research in Neuropsychology and Cognitive Behavioral Intervention. Coimbra. Portugal
  • Ganho-Ávila, Ana; University of Coimbra. Faculty of Psychology and Educational Sciences. Center for Research in Neuropsychology and Cognitive Behavioral Intervention. Coimbra. Portugal
Int. j. clin. health psychol. (Internet) ; 23(1): 1-16, ene.-abr. 2023. ilus, tab, graf
Artículo en Inglés | IBECS | ID: ibc-213100
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background/

Objective:

Anxiety disorders are highly prevalent and negatively impact daily functioning and quality of life. Transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (dlPFC), especially in the right hemisphere impacts extinction learning; however, the underlying neural mechanisms are elusive. Therefore, we aimed to investigate the effects of cathodal tDCS stimulation to the right dlPFC on neural activity and connectivity patterns during delayed fear extinction in healthy participants.

Methods:

We conducted a two-day fear conditioning and extinction procedure. On the first day, we collected fear-related self-reports, clinical questionnaires, and skin conductance responses during fear acquisition. On the second day, participants in the tDCS group (n = 16) received 20-min offline tDCS before fMRI and then completed the fear extinction session during fMRI. Participants in the control group (n = 18) skipped tDCS and directly underwent fMRI to complete the fear extinction procedure. Whole-brain searchlight classification and resting-state functional connectivity analyses were performed.

Results:

Whole-brain searchlight classification during fear extinction showed higher classification accuracy of threat and safe cues in the left anterior dorsal and ventral insulae and hippocampus in the tDCS group than in the control group. Functional connectivity derived from the insula with the dlPFC, ventromedial prefrontal cortex, and inferior parietal lobule was increased after tDCS.

Conclusion:

tDCS over the right dlPFC may function as a primer for information exchange among distally connected areas, thereby increasing stimulus discrimination. The current study did not include a sham group, and one participant of the control group was not randomized. Therefore, to address potential allocation bias, findings should be confirmed in the future with a fully randomized and sham controlled study. (AU)
Asunto(s)


Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Trastornos de Ansiedad / Corteza Prefrontal / Estimulación Transcraneal de Corriente Directa Límite: Humanos Idioma: Inglés Revista: Int. j. clin. health psychol. (Internet) Año: 2023 Tipo del documento: Artículo Institución/País de afiliación: Korea Brain Research Institute/Republic of Korea / University of Coimbra/Portugal

Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Trastornos de Ansiedad / Corteza Prefrontal / Estimulación Transcraneal de Corriente Directa Límite: Humanos Idioma: Inglés Revista: Int. j. clin. health psychol. (Internet) Año: 2023 Tipo del documento: Artículo Institución/País de afiliación: Korea Brain Research Institute/Republic of Korea / University of Coimbra/Portugal
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