A case of persistent IgE sensitisation almost two decades following ampicillin anaphylaxis
Allergol. immunopatol
; 51(2): 126-129, 01 mar. 2023. tab, graf
Article
en En
| IBECS
| ID: ibc-216815
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background:
Although most immunoglobulin E (IgE)-mediated penicillin allergy wanes with time, sensitisation may occasionally persist for many years. Previous reports on the loss of penicillin-specific IgE sensitisation were based on non-anaphylaxis cases and, although uncommon, persistent sensitisation may still be possible in the minority of cases.Objective:
This case highlights that irrespective of the elapsed duration since the index reaction, it is important to remain vigilant when approaching patients with a history of severe reactions. Material andMethods:
We described a case of persistent IgE sensitisation almost two decades following ampicillin anaphylaxis.Results:
A 78-year-old male with a history of perioperative penicillin anaphylaxis in 2003 was referred for allergy workup in 2022 before his knee joint replacement surgery. The patient had strictly avoided all beta-lactams since the index reaction. However, his penicillin-specific sensitisation persisted, evidenced by positive skin tests (with generalised urticaria after intradermal testing) and basophil activation tests.Conclusion:
To our knowledge, this was the first case of positive BAT tested around two decades following the index reaction. This case illustrates that a cautious approach may still be warranted in patients with a history of severe reaction to penicillin regardless of the duration since the reported index reaction (AU)Palabras clave
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Penicilinas
/
Hipersensibilidad a las Drogas
/
Anafilaxia
/
Antibacterianos
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Allergol. immunopatol
Año:
2023
Tipo del documento:
Article