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Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma: systematic review and meta-analysis
González-Moles, Miguel Ángel; Porras-Carrique, Teresa de; Ramos-García, Pablo.
Afiliación
  • González-Moles, Miguel Ángel; University of Granada. School of Dentistry. Biohealth Research Institute (Ibs.Granada). Granada. Spain
  • Porras-Carrique, Teresa de; University of Granada. School of Dentistry. Biohealth Research Institute (Ibs.Granada). Granada. Spain
  • Ramos-García, Pablo; University of Granada. School of Dentistry. Biohealth Research Institute (Ibs.Granada). Granada. Spain
Med. oral patol. oral cir. bucal (Internet) ; 28(3): e229-e237, may. 2023. tab, ilus, graf, mapas
Artículo en Inglés | IBECS | ID: ibc-220060
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT

Background:

Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology. The importance of the association between hepatic disease and OLP lies in the fact that many of these disorders (HC, HB, cirrhosis, hepatic steatosis) behave as risk factors for hepatocellular carcinoma. Material and

methods:

We searched PubMed, Embase, Web of Science, and Scopus for studies published before January 2022. We evaluated the quality of studies (Joanna Briggs Institute tool). We performed meta-analyses, investigated the heterogeneity between studies, and we also carried out subgroups, meta-regression, and small-study effects analyses. 146 studies (21,187 patients) were included in this study. Our study aims to evaluate current evidence on the prevalence and magnitude of association between hepatic diseases (especially those with risk of malignancy), hepatocellular carcinoma and OLP.

Results:

Our results suggest that patients with OLP present a significant tendency to the development of hepatitis B (OR=1.62, 95%CI=1.01-2.40, p=0.02), hepatitis C (OR=4.09, 95%CI=2.77-6.03, p<0.001), cirrhosis (OR=5.58, 95%CI=1.83-16.96, p=0.002), hepatic steatosis (OR=5.71, 95%CI=0.97-33.60, p=0.05) and hepatocellular carcinoma (OR=3.10,95%CI=1.14-8.43, p=0.03).

Conclusions:

Patients with OLP should be investigated to rule out the presence of hepatic disease, which can lead to hepatocellular carcinoma, allowing an early diagnosis that would help to a better approach to liver disease and a notable improvement in prognosis in terms of both progression and severity. (AU)
Asunto(s)


Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Liquen Plano Oral / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humanos Idioma: Inglés Revista: Med. oral patol. oral cir. bucal (Internet) Año: 2023 Tipo del documento: Artículo Institución/País de afiliación: University of Granada/Spain

Texto completo: Disponible Colección: Bases de datos nacionales / España Base de datos: IBECS Asunto principal: Liquen Plano Oral / Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humanos Idioma: Inglés Revista: Med. oral patol. oral cir. bucal (Internet) Año: 2023 Tipo del documento: Artículo Institución/País de afiliación: University of Granada/Spain
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