Is Dexamethasone superior to Ketorolac in reducing pain, swelling and trismus following mandibular third molar removal? A split mouth triple-blind randomized clinical trial
Med. oral patol. oral cir. bucal (Internet)
; 26(2): e141-e150, Mar. 2021. tab, ilus, graf
Article
en En
| IBECS
| ID: ibc-224433
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background: The preemptive use of anti-inflammatory drugs, such as corticosteroids and NSAIDs, has the po-tential to reduce pain, swelling and trismus following oral surgery. The aim of this study was to compare theefficacy of dexamethasone and ketorolac tromethamine in reducing pain, swelling and trismus after mandibularthird molar removal.Material and Methods: The researches implemented a triple-blind, randomized clinical trial. The study was con-ducted with ASA I individuals aging between 18 and 35 years, which were randomized and submitted to twointerventions, one with 8mg dexamethasone and the other with 20mg ketorolac tromethamine given 1h before theprocedure. The primary predictor variable was the use of dexamethasone or ketorolac. The primary outcome vari-able was the postoperative pain level, measured with a Visual Analogue Scale. The secondary outcome variableswere the amount of rescue analgesic consumed, swelling and trismus. Repeated-measures ANOVA and t-test forpaired samples were used to compare the means. Significance was set at p < 0.05.Results: Fifty individuals were randomized and allocated to intervention, and the sample was composed of 40subjects who completed the study (27 female and 13 male). Dexamethasone, when compared to ketorolac trometh-amine, showed a significantly higher reduction in pain level at 8h, 16h, 24h, 32h, 40h and 72h, in swelling and tris-mus at 24h, 48h, 72h and 7 days and in total number of rescue analgesics taken up to 72h postoperative (p < 0.05). Conclusions: The clinical performance of dexamethasone in controlling pain, swelling and trismus after mandibularthird molar removal was superior to ketorolac tromethamines.(AU)
Palabras clave
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Dolor Postoperatorio
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Extracción Dental
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Trismo
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Antiinflamatorios
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Tercer Molar
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Med. oral patol. oral cir. bucal (Internet)
Año:
2021
Tipo del documento:
Article