The genotypes and virulence attributes of C. albicans isolates from oral leukoplakia / Los genotipos y atributos de virulencia de aislamientos de C. albicans de leucoplasia oral
Med. oral patol. oral cir. bucal (Internet)
; 26(6): e786-e794, Nov. 2021. tab
Artículo
en Inglés
| IBECS
| ID: ibc-224683
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background:
There is a debate as to whether some types of oral leucoplakias (OL) are caused by Candida species,and whether they contribute to the malignant transformation, associated with a minority of such lesions. As nodetailed population analysis of yeast isolates from OL is available, we evaluated the virulence attributes, and geno-types of 35 C. albicans from OL, and compared their genotypes with 18 oral isolates from healthy individuals.Material andMethods:
The virulence traits evaluated were esterase, phospholipase, proteinase, haemolysin andcoagulase production, and phenotypic switching activity, and yeast adherence and biofilm formation. DNA fromOL and control yeasts were evaluated for A, B or C genotype status.Results:
Phospholipase, proteinase, and coagulase activity and biofilm formation was observed in 80%, 66%, 97% and 77 % of the isolates, respectively. Phenotypic switching was detected in 8.6%, while heamolytic, and ester-ase activity and adherence were noted in all isolates.Conclusions:
The genotype A was predominant amongst both the OL and control groups. Due to the small samplesize of our study a larger investigation to define the role of candidal virulent attributes in the pathogenicity of OLis warranted, and the current data should serve as a basis until then.(AU)
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
España
Base de datos:
IBECS
Asunto principal:
Candida albicans
/
Leucoplasia Bucal
/
Factores de Virulencia
/
Boca
Límite:
Humanos
Idioma:
Inglés
Revista:
Med. oral patol. oral cir. bucal (Internet)
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
University of Sharjah/Hong Kong
/
University of Sri Jayewardenepura/Sri Lanka