The crosstalk between autophagy and myeloid-derived suppressor cell responses in cancer
Clin. transl. oncol. (Print)
; 25(10): 2832-2840, oct. 2023. ilus
Article
en En
| IBECS
| ID: ibc-225063
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
The development of cancers is aided by the accumulation of myeloid-derived suppressor cells (MDSCs) within tumors, which are highly effective at suppressing anti-tumor immune responses. Direct cell-to-cell interaction and the production of immunosuppressive mediators have both been proposed as pathways for MDSC-mediated suppression of anti-tumor immune responses. The majority of current cancer treatments focus on altering the development and activity of MDSCs so that they have more of an immunogenic character. Autophagy is a catabolic system that contributes to the breakdown of damaged intracellular material and the recycling of metabolites. However, depending on the stage of tumor growth, autophagy can play both a prophylactic and a therapeutic function in carcinogenesis. However, several indirect lines of research have indicated that autophagy is a significant regulator of MDSC activity. The purpose of this work was to outline the interactions between MDSC and autophagy in cancer (AU)
Palabras clave
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Autofagia
/
Células Supresoras de Origen Mieloide
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2023
Tipo del documento:
Article