Pulmonary Function in People Living With Human Immunodeficiency Virus: A Meta-Analysis
Arch. bronconeumol. (Ed. impr.)
; 60(4): 200-206, abr.2024. tab, graf
Artículo
en Inglés
| IBECS
| ID: ibc-232041
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background:
HIV can infect bronchial epithelial cells rendering individuals susceptible to lung damage. Our objective was to determine the effects of human immunodeficiency virus (HIV) infection on pulmonary function tests.Methods:
We performed a meta-analysis after conducting a literature search in PubMed, Embase, Cochrane Library and Virtual Health Library databases from inception to December 31st, 2022. We employed the inverse variance method with a random effects model to calculate the effect estimate as the mean difference (MD) and 95% confidence interval (CI). We calculated the heterogeneity with the I2 statistic and performed a meta-regression analysis by age, sex, smoking, CD4 T-cells count and antiretroviral therapy. We also conducted a sensitivity analysis according to the studies publication date, and excluding the study with the greatest weight in the effect. The PROSPERO registry number was CRD42023401105.Results:
The meta-analysis included 20 studies, with 7621 living with HIV and 7410 control participants. The pooled MD (95%CI) for the predicted percentage of FEV1, FVC and DLCO were −3.12 (−5.17, −1.06); p=0.003, −1.51 (−3.04, 0.02); p=0.05, and −5.26 (−6.64, −3.87); p<0.001, respectively. The pooled MD for FEV1/FVC was −0.01 (−0.02, −0.01); p=0.002. In all cases, there was a considerable heterogeneity. The meta-regression analysis showed that among studies heterogeneity was not explained by patient age, smoking, CD4 T-cells count or antiretroviral therapy.Conclusion:
Pulmonary function tests are impaired in people living with HIV, independently of age, smoking, CD4 T-cells count, and geographical region. (AU)
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Colección:
Bases de datos nacionales
/
España
Base de datos:
IBECS
Asunto principal:
Tabaquismo
/
Bronquios
/
Recuento de Células
/
VIH
/
Heterogeneidad Genética
/
Células Epiteliales Alveolares
/
Pulmón
Límite:
Humanos
Idioma:
Inglés
Revista:
Arch. bronconeumol. (Ed. impr.)
Año:
2024
Tipo del documento:
Artículo
Institución/País de afiliación:
University Hospital Royo Villanova/Spain