Response to budesonide among atopic and non-atopic infants/preschoolers with recurrent wheezing
Allergol. immunopatol
; 38(1): 31-36, ene.-feb. 2010. tab
Article
en En
| IBECS
| ID: ibc-77099
Biblioteca responsable:
ES1.1
Ubicación: BNCS
RESUMEN
Background The treatment in non-atopic young children with recurrent wheezing remains controversial. Objective The aim of the study was to compare the response of inhaled budesonide in atopic versus non-atopic infants/preschoolers with recurrent wheezing (more than three episodes in the last year or one episode per month in the last three months). Methods One hundred and seventy three infants/preschoolers (mean age 1.58¡À0.9 yrs) with recurrent wheezing without previous use of inhaled corticosteroids were enrolled and divided into two categories atopics (eosinophils in peripheral blood ¡Ý4%) and non-atopics (<4%). Both groups were treated with budesonide (200mcg bid delivered by MDI and spacer) for three months. The primary outcome was the prevalence of wheezing exacerbation episodes at the end of the treatment. Results Thirty-seven out of 173 (21.4%) were atopics and they were significantly younger, more frequently with a father with asthma, maternal grandparents with asthma and rhinitis, paternal and maternal grandparents with eczema, and higher number of wheezing episodes in the last year than non-atopics. At the end of the study, among those with good compliance (>70% of the weekly doses), the proportion of wheezing episodes were similar among atopics and non-atopics (57.7% vs. 44.1%, p=0.25, respectively); the number of exacerbations requiring emergency department (ED) visits and hospital admission were also similar. Conclusion Regular budesonide therapy may decrease the episodes of wheezing in infants/preschoolers with recurrent wheezing, independently of atopy
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Atención Primaria de Salud
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Recurrencia
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Asma
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Corticoesteroides
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Budesonida
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Hipersensibilidad Inmediata
Tipo de estudio:
Diagnostic_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Allergol. immunopatol
Año:
2010
Tipo del documento:
Article