Risk of endometrial cancer after RRSO in BRCA 1/2 carriers: a multicentre cohort study / Riesgo de cáncer de endometrio después de RRSO en portadoras de BRCA 1/2: un estudio de cohorte multicéntrico
Clin. transl. oncol. (Print)
; 26(4): 1033-1037, Abr. 2024.
Article
en En
| IBECS
| ID: ibc-VR-66
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Objective: To know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after risk-reducing salpingo-oophorectomy (RRSO). Methods: The study cohort included data from 857 women with BRCA mutations who underwent RRSO visited four hospitals in Catalonia, Spain, from January 1, 1999 to April 30, 2019. Standardized incidence ratio (SIR) of EC was calculated in these patients using data from a regional population-based cancer registry. Results: After RRSO, eight cases of EC were identified. Four in BRCA 1 carriers and four in BRCA2 carriers. The expected number of cases of EC was 3.67 cases, with a SIR of 2.18 and a 95% CI (0.933.95). Conclusions: In our cohort, the risk of EC in BRCA1/2 carriers after RRSO is not greater than expected. Hysterectomy is not routinely recommended for these patients.(AU)
Palabras clave
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Oftalmología
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Dolor
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Neoplasias Pancreáticas
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Cuidados Posoperatorios
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Periodo Posoperatorio
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Complicaciones del Embarazo
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Atención Primaria de Salud
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Investigación
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Fibrilación Atrial
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Delitos Sexuales
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Evaluation_studies
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Guideline
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Aspecto:
Determinantes_sociais_saude
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Patient_preference
Límite:
Humans
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Female
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Male
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Aged
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Adolescent
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Child
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Newborn
País/Región como asunto:
Europa
/
Africa
Idioma:
En
/
Es
Revista:
Rev. esp. cir. ortop. traumatol. (Ed. impr.)
/
An. pediatr. (2003. Ed. impr.)
/
Aten. prim. (Barc., Ed. impr.)
/
Clin. transl. oncol. (Print)
/
Clín. investig. ginecol. obstet. (Ed. impr.)
/
Enferm. infecc. microbiol. clín. (Ed. impr.)
/
Gastroenterol. hepatol. (Ed. impr.)
/
Int. microbiol
/
Interv. psicosoc. (Internet)
/
Med. clín (Ed. impr.)
Año:
2022
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2023
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2021
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2024
Tipo del documento:
Article