Inhibition of bovine brain acetylcholinesterase by aluminum
Braz. j. med. biol. res
; 27(11): 2635-8, Nov. 1994. graf
Article
en En
| LILACS
| ID: lil-153985
Biblioteca responsable:
BR1.1
ABSTRACT
We report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50 = 4.1 x 10-12M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were performed using acetylcholine bromide in a buffered pH 7.4 solution at 37§C. The relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent inhibitor of AChE
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Acetilcolinesterasa
/
Técnicas In Vitro
/
Cerebro
/
Aluminio
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1994
Tipo del documento:
Article