Effects of piperitenone oxide on the intestinal smooth muscle of the guinea pig
Braz. j. med. biol. res
; 30(6): 787-91, jun. 1997. ilus
Article
en En
| LILACS
| ID: lil-194181
Biblioteca responsable:
BR1.1
ABSTRACT
We investigated the effects of piperitenone oxide (PO), a major constituent of the essential oil of Mentha x villosa, on the guinea pig ileum. PO (30 to 740 mug/ml) relaxed basal tonus without significantly alterating the resting membrane potential. In addition, PO relaxed preparations precontracted with either 60 mM K+ or 5 mM tetraethyl-ammonium in a concentration-dependent manner. At concentrations from 0.1 to 10 mug/ml PO potentiated acetylcholine-induced contractions, while higher concentrations (>30 mug/ml) blocked this response. These higher PO concentrations also inhibited contractions induced by 60 mM K+. PO also blocked the components of acetylcholine contraction which are not sensitive to nifedipine or to solutions with nominal zero Ca2+ and EGTA. These results show that PO is a relaxant of intestinal smooth muscle and suggest that this activity may be mediated at least in part by an intracellular effect.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Cloruro de Potasio
/
Terpenos
/
Ansiolíticos
/
Aceites de Plantas
/
Fármacos Gastrointestinales
/
Bloqueadores de los Canales de Calcio
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Nifedipino
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Acetilcolina
/
Compuestos de Tetraetilamonio
/
Íleon
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1997
Tipo del documento:
Article