Effect of vasoactive drugs on muscle fibre types and capillares
Acta cient. venez
; 45(3): 199-206, 1994. tab, graf
Article
en En
| LILACS
| ID: lil-217161
Biblioteca responsable:
BR1.1
RESUMO
The effect of nitroglycerin, nifedipine, diltiazem or propranolol on fibre types and capillaries was studied in extensor digitorum longus (EDL) and soleus (S) muscles of the rat. In EDL muscle nifedipine increased the proportion of type I fibres (7.9 percent +/- 1.7 vs. 4.7 percent +/- 2.7). Nitroglycerin and dialtiazem decreased IIB fibres (40.7 percent +/- 10.6 and 37.3 percent +/- 14.6 respectively vs. 52.3 percent +/- 9.4). Propranolol increased IIB fibres to 66.3 percent +/- 8.1, while reducing IIA fibres (25.3 percent +/- 6.6 vs. 42.2 percent +/- 6.9). No changes in fibre type proportion were found in S muscle. Capillary density was increased in EDL by nitroglycerin (965 +/- 171 vs. 818 +/- 98 cap/mm2). Propranolol had a dual effect on this parameter, decreasing it in EDL to 570 +/- 85 and augmenting it in S (754 +/- 117 vs. 601 +/- 121). No change was found in capillary to fibre ratio with any of the drugs either in EDL or S muscles. In EDL all the drugs except propranolol, which had the opposite effect, decreased the area of IIA fibre per capillary around 20 percent this effect can be interpreted as a reduction of diffusion distance from blood to fibre
Buscar en Google
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Vasodilatadores
/
Capilares
/
Fibras Musculares Esqueléticas
Límite:
Animals
Idioma:
En
Revista:
Acta cient. venez
Asunto de la revista:
CIENCIA
Año:
1994
Tipo del documento:
Article
Pais de publicación:
VE
/
VENEZUELA