Enfermedad ósea de Paget: diagnóstico diferencial de lesiones osteolíticas: caso clínico / Paget disease of the bone: differential diagnosis of osteolytic lesions: report of 1 case
Rev. méd. Chile
; 126(10): 1229-33, oct. 1998. ilus
Article
en Es
| LILACS
| ID: lil-242708
Biblioteca responsable:
CL1.1
ABSTRACT
We report a 48 years old female with Paget's disease of the bone who consulted for leg pain. After exhaustive examination a magnetic nuclear resonance revealed a 7 mm intradural schwannoma that was resected without improvement. Four years later, with generalized, progressive bone pains, several osteolytic rib lesions were detected. A bone scintigraphy showed extensive areas of hyperfixation of Tc99 DPM. Biochemical tests were normal with exception of very high serum alkaline phosphatases. Looking for some neoplastic disease, a breast nodule was detected by mammography. Biopsy demonstrated benign disease. Finally, a rib lesion biopsy disclosed diagnosis of Paget's disease of the bone. Treatment with calcitonin, etidronate and vitamin D resulted in partial clinical improvement, reduction of abnormal isotope hyperfixation in bone scintigraphy and of serum alkaline phosphatase levels
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Osteítis Deformante
/
Osteólisis
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Female
/
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
1998
Tipo del documento:
Article
Pais de publicación:
Chile