Efecto comparativo de policosanol con dos inhibidores de la HMG-CoA reductasa en el tratamiento de la hipercolesterolemia tipo II / Comparative effects of policosanol and two HMG-CoA reductase inhibitors on type II hypercholesterolemia
Rev. méd. Chile
; 127(3): 286-94, mar. 1999. tab
Article
en Es
| LILACS
| ID: lil-243792
Biblioteca responsable:
CL1.1
ABSTRACT
Background:
Policosanol is a new cholesterol lowering agent derived from sugar cane.Aim:
To compare the cholesterol lowering efficacy of policosanol with HMG CoA inhibitors. Patients andmethods:
Patients with a LDL cholesterol over 160 mg/dl were studied. If, after 6 weeks of diet, cholesterol persisted elevated, they were doubly blind randomized to receive policosanol 10 mg/day (55 patients), lovastatin 20 mg/day (26 patients) or simvastatin 10 mg/day (25 patients). Serum cholesterol was measured again after 8 weeks of therapy.Results:
Initial demographic and laboratory data were similar among treatment groups. A 24 percent LDL cholesterol reduction was obtained with policosanol, compared with a 22 percent reduction with lovastatin and a 15 percent reduction with simvastatin. HDL cholesterol significantly increased in patients on policosanol and did not change in the other treatment groups. Adverse effects of policosanol were mild and unspecific. No changes in hepatic enzymes were observed.Conclusions:
Policosanol is a safe and effective cholesterol reducing agent
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Lovastatina
/
Simvastatina
/
Hipercolesterolemia
/
Anticolesterolemiantes
Tipo de estudio:
Clinical_trials
/
Guideline
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
1999
Tipo del documento:
Article