Relación entre leptina e insulina sanguíneas en mujeres chilenas obesas y no obesas / Relationship between leptin and insulin blood levels in obese and lean chilean women
Rev. méd. Chile
; 128(2): 154-61, feb. 2000. tab, graf
Article
en Es
| LILACS
| ID: lil-258112
Biblioteca responsable:
CL1.1
ABSTRACT
Background:
Leptin, a product of ob gene and insulin blood levels, are proportional to the amount of adipose tissue. Insulin could have an independent regulatory effect on leptin secretion.Aim:
To assess the relationship between serum leptin and plasma insulin levels in obese and lean Chilean women. Material andmethods:
One hundred forty five women, aged 20 to 60 years old, were studied. Weight, height, waist and hip circumference, fasting blood glucose, insulin and leptin levels were measured. Insulin resistance was assessed using the homeostasis model assessment. The relationship between different variables was determined using multiple linear regression, variance analysis and non parametric correlation.Results:
Leptin serum concentrations were positively correlated with body mass index, insulin plasma levels and degree of insulin resistance. The association of leptin with insulin was independent of body mass index and persisted after adjustments by body fat distribution and age.Conclusions:
Insulin and insulin resistance are associated to high blood leptin levels and this association is independent of the degree of adiposity and body fat distribution
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Leptina
/
Insulina
/
Obesidad
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2000
Tipo del documento:
Article
/
Project document
Pais de publicación:
Chile