Fosforilación en células eucarióticas: papel de fosfatasas y quinasas en la biología, patogenia y control de protozoosis tisulares y sanguíneas / Phosphorylation in eukaryotic cells: role of phosphatases and kinases in biology, pathogenesis and control of intracellular and bloodstream protozoa
Rev. méd. Chile
; 128(10): 1150-60, oct. 2000. ilus
Article
en Es
| LILACS
| ID: lil-277210
Biblioteca responsable:
CL1.1
RESUMO
Cells respond to environmental or cellular changes, rapidly switching protein activities from one state to another. In eukaryotes, a way to achieve these changes is through protein phosphorylation cycles, involving independent protein kinase and protein phosphatase activities. Current evidences show that phosphatases and kinases are also involved in the molecular basis of immune response and in diseases such as diabetes obesity and Alzheimer. In protozoan parasites like Trypanosoma and Leishmania, several kinases and phosphatases have been identified, many of them have been cloned but in several cases their biological role remains undetermined. In this review, the state-of-the art is summarized and the role of phosphatases and kinases in biological phenomena such as remodeling, invasion and pathogenic capacity of protozoan parasites is described. The real chance to use these components of signal transduction pathways as target for chemotherapeutic intervention is also discussed
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Fosforilación
/
Infecciones por Protozoos
/
Proteínas Tirosina Quinasas
/
Proteínas Serina-Treonina Quinasas
Tipo de estudio:
Etiology_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2000
Tipo del documento:
Article