Encefalopatía hepática crónica: rol de niveles sanguíneos elevados de manganeso y su relación con lesiones en ganglios basales en la resonancia magnética nuclear de cerebro: caso clínico / Chronic hepatic encephalopathy is associated whith high serum manganese levels and basal ganglia hyperintensities: report of case
Rev. méd. Chile
; 129(9): 1051-1055, sept. 2001. ilus
Artículo
en Español
| LILACS
| ID: lil-302036
Biblioteca responsable:
CL1.1
RESUMO
Chronic hepatic encephalopathy (CHE) is a disabling complication of chronic liver failure and porto-systemic shunt.The pathogenesis of CHE remains unclear but increased levels of ammonia are a basic feature. Several clinical and experimental observations support a role for manganese (Mn) in the pathogenesis of this disorder. Increased blood levels of Mn have been described in patients with CHE and this could lead to its accumulation on the basal ganglia and characteristic hyperintensities of basal ganglia as seen on magnetic resonance imaging (MRI) of the brain. We report on the clinical features and characteristic radiologic findings of a patient who presented with the neurologic syndrome of CHE and who had very high blood levels of Mn in the absence of an occupational exposure to this metal. Our report supports the hypothesis that Mn has a role in the pathogenesis of CHE and also suggests that brain MRI is a useful marker of the brain metabolic repercusion due to CHE
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
ODS3 - Meta 3.9 Reducir las muertes producidas por productos químicos peligrosos y la contaminación del aire, el agua y el suelo
Problema de salud:
Exposiciones Ocupacionales
Base de datos:
LILACS
Asunto principal:
Ganglios Basales
/
Encefalopatía Hepática
/
Enfermedad Crónica
/
Manganeso
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2001
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL