Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae)
Rev. Inst. Med. Trop. Säo Paulo
; 44(2): 109-112, Mar.-Apr. 2002. tab
Article
en En
| LILACS
| ID: lil-308015
Biblioteca responsable:
BR1.1
ABSTRACT
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Triterpenos
/
Tripanocidas
/
Trypanosoma cruzi
Límite:
Animals
Idioma:
En
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Asunto de la revista:
MEDICINA TROPICAL
Año:
2002
Tipo del documento:
Article
País de afiliación:
Brasil