Immunological basis of septal fibrosis of the liver in Capillaria hepatica-infected rats
Braz. j. med. biol. res
; 36(9): 1201-1207, Sept. 2003. ilus, graf
Article
en En
| LILACS
| ID: lil-342851
Biblioteca responsable:
BR1.1
ABSTRACT
Rats infected with the helminth Capillaria hepatica regularly develop septal fibrosis of the liver similar to that induced by repeated ip injections of pig serum. Fibrosis starts when the focal parasitic lesions begin to show signs of resorption, thus suggesting an immunologically mediated pathogenesis of this fibrosis. To explore this possibility, the development of C. hepatica-related hepatic fibrosis was observed in rats exposed to worm antigens from the first neonatal day onward. Wistar rats (150 g) were either injected ip with an extract of C. hepatica eggs (protein concentration 1 mg/ml) or received immature eggs by gavage from the first neonatal day until adult life and were then infected with 500 embryonated eggs. Changes were monitored on the basis of serum levels of anti-worm antibodies and hepatic histopathology. Rats submitted to immunological oral tolerance markedly suppressed C. hepatica-related serum antibodies and septal fibrosis of the liver when infected with the helminth later on. Tolerance trials with ip injections of worm antigens gave essentially negative results. The partial suppression of septal fibrosis of the liver after the induction of immunological tolerance to C. hepatica antigens in rats indicates an immunological basis for the fibrosis and emphasizes the importance of immunological factors in the pathogenesis of hepatic fibrosis
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Capillaria
/
Infecciones por Enoplida
/
Cirrosis Hepática Experimental
/
Parasitosis Hepáticas
/
Antígenos Helmínticos
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil