Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: análisis de la evidencia epidemiológica y experimental / Pesticide exposure and reproductive and birth defects: critical analysis of epidemiological and experimental evidence
Rev. méd. Chile
; 132(7): 873-879, jul. 2004. tab
Article
en Es
| LILACS
| ID: lil-366590
Biblioteca responsable:
CL12.1
ABSTRACT
Several epidemiological studies link pesticide exposure to reproductive and developmental toxicity. However, additional studies have shown little or no evidence to support such relationship. On the other hand, experimental data show that some pesticides may indeed alter the reproductive function or produce birth defects (as evidenced by intrauterine death, in utero growth retardation, visceral and skeletal malformations or functional deficits) in laboratory animals. This review is a critical analysis of the epidemiological and experimental evidence available to date, that links pesticide exposure with induction of reproductive or developmental defects. Factors that must be considered when establishing a cause-effect relationship are also discussed, including the shape of the dose-response curve, exposure to pesticides in chemical mixtures and the influence of genetic background.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Plaguicidas
/
Exposición Profesional
/
Enfermedades de los Trabajadores Agrícolas
Límite:
Animals
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2004
Tipo del documento:
Article
/
Project document
País de afiliación:
Chile
Pais de publicación:
Chile