Tiempo de exposición al gluten y marcadores de riesgo de diabetes mellitus insulino dependiente en pacientes celíacos / Risk markers for insulin-dependent diabetes mellitus and duration of exposure to gluten in celiac patients
Rev. méd. Chile
; 132(8): 979-984, ago. 2004. tab
Artículo
en Español
| LILACS
| ID: lil-384194
Biblioteca responsable:
CL12.1
RESUMO
Background: Celiac patients are at high risk of developing insulin-dependent diabetes mellitus, a condition that has a long pre-diabetic period. During this lapse, anti-islet cell antibodies serve as markers for future disease. This may be related with the duration of the exposure to gluten. Aim: To test the hypothesis that long term adherence to a gluten free diet decreases the frequency of risk markers for insulin dependent diabetes mellitus during adolescence and early adulthood. Patients and methods: 158 celiac patients were classified as: G1, (n=30 patients) studied at the time of diagnosis; G2 (n=97 patients) exposed to gluten as a result of non compliance with the gluten free diet and, G3 (n=31 patients) who had maintained a long term, strict gluten free diet. Isotype IgG anti-islet cell antibodies were detected by indirect immunofluorescence using monkey pancreas; results were reported in Juvenile Diabetes Foundation (JDF) units. Results: Celiac patients exposed to a gluten containing diet had a significantly higher prevalence of anti-islet cell antibodies than those who had been exposed only briefly (p <0.017). In addition, a significantly higher prevalence of anti-islet cell antibodies was observed in those patients whose exposure to gluten was longer than 5 years than in those whose exposure was shorter (p <0.02). Conclusions: Celiac patients long exposed to gluten have a significantly higher prevalence of anti-islet cell antibodies than those exposed for a short period. This fact supports the hypothesis that the development of these antibodies is associated with the length of the exposure to gluten (Rev Méd Chile 2004; 132: 979-84).
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
ODS3 - Meta 3.9 Reducir las muertes producidas por productos químicos peligrosos y la contaminación del aire, el agua y el suelo
Problema de salud:
Exposiciones Ocupacionales
Base de datos:
LILACS
Asunto principal:
Enfermedad Celíaca
/
Islotes Pancreáticos
/
Diabetes Mellitus Tipo 1
/
Glútenes
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Niño, preescolar
/
Femenino
/
Humanos
/
Lactante
/
Masculino
/
Recién nacido
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2004
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Clínico Exequiel González Cortés/CL
/
Hospital Luis Calvo Mackenna/CL
/
Hospital San Borja Arriarán/CL
/
Universidad de Chile/CL