Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Mem. Inst. Oswaldo Cruz
; 100(supl.1): 177-180, Mar. 2005. ilus
Article
en En
| LILACS
| ID: lil-402196
Biblioteca responsable:
BR1.1
RESUMO
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Periodontitis
/
Receptores Proteinasa-Activados
Límite:
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Brasil
/
Canadá