Heterotopic transplantation of glycerin-preserved trachea: effect of respiratory epithelium desquamation on acute rejection
Braz. j. med. biol. res
; 38(7)July 2005. ilus
Article
en En
| LILACS
| ID: lil-403862
Biblioteca responsable:
BR1.1
ABSTRACT
An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 ± 0.43, P <= 0.001) when compared to the autograft and glycerin-preserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerin-preserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Tráquea
/
Trasplante Heterotópico
/
Mucosa Respiratoria
/
Crioprotectores
/
Glicerol
/
Rechazo de Injerto
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL