Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice
Braz. j. med. biol. res
; 38(12): 1867-1872, Dec. 2005. ilus
Article
en En
| LILACS
| ID: lil-417193
Biblioteca responsable:
BR1.1
ABSTRACT
Depression found in Parkinson disease (PD) usually responds to selective serotonin reuptake inhibitors (SSRIs). Drugs that modify experimental neuroleptic catalepsy (NC) might affect extrapyramidal symptoms in PD. Therefore, the effects of SSRIs on NC were tested in mice, 26-36 g, separated by sex. Catalepsy was induced with haloperidol (H; 1 mg/kg, ip) and measured at 30-min intervals using a bar test. An SSRI (sertraline, ST; paroxetine, PX; fluoxetine) or vehicle (C) was injected ip 30 min before H. Dunnett's test was used for comparison of means. ST (1-5 mg/kg) or PX (1-5 mg/kg) attenuated NC, with a similar inhibition found in both sexes (5 mg/kg, 180 min ST - males 124 ± 10 vs 714 ± 15 s in C; females 116 ± 10 vs 718 ± 6 s in C; PX - males 106 ± 10 vs 714 ± 14 s in C; females 102 ± 10 vs 715 ± 14 s in C). At 0.3 mg/kg, neither of these drugs affected NC. Fluoxetine (1-25 mg/kg) also inhibited catalepsy, although the effect was not dose-dependent; no differences were observed between males and females (5 mg/kg, 180 min males, 185 ± 14 vs 712 ± 14 s in C; females, 169 ± 10 vs 710 ± 19 s in C). For these SSRIs, maximal inhibition of NC was obtained with 5 mg/kg, 180 min after H. These results are consistent with the hypothesis that serotonergic mechanisms modulate nigrostriatal transmission, and suggest that SSRIs are possibly safe in depressive PD patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Catalepsia
/
Fluoxetina
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Paroxetina
/
Sertralina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2005
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil