Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl-beta-cyclodextrin: study of morphology and cytotoxicity
Rev. ciênc. farm. básica apl
; 27(3): 207-212, 2006. ilus, graf
Article
en En
| LILACS
| ID: lil-466202
Biblioteca responsable:
BR33.1
ABSTRACT
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-)bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheraland central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in2-hydroxypropyl- beta-cyclodextrin (HP-beta -CD). Differential scanning calorimetry, scanning electron microscopy andX-Ray diffraction analysis showed structural changes inthe complex. In preliminary toxicity studies, the cellviability tests revealed that the inclusion complex decreased the toxic effect (p smaller that 0.001) produced by S(-) bvc.These results suggest that the S(-) bvcHP- beta-CD inclusion complex represents a promising agent for the treatment of regional pain.
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Dolor
/
Bupivacaína
/
Rastreo Diferencial de Calorimetría
/
Microscopía Electrónica de Rastreo
/
Cuerpos de Inclusión
/
Beta-Ciclodextrinas
Idioma:
En
Revista:
Rev. ciênc. farm. básica apl
Asunto de la revista:
FARMACOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Brasil