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Interobserver agreement of gleason score and modified gleason score in needle biopsy and in surgical specimen of prostate cancer
Veloso, Sergio G; Lima, Mario F; Salles, Paulo G; Berenstein, Cynthia K; Scalon, Joao D; Bambirra, Eduardo A.
Afiliación
  • Veloso, Sergio G; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
  • Lima, Mario F; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
  • Salles, Paulo G; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
  • Berenstein, Cynthia K; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
  • Scalon, Joao D; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
  • Bambirra, Eduardo A; Mario Penna Hospital. Section of Urology. Belo Horizonte. BR
Int. braz. j. urol ; 33(5): 639-651, Sept.-Oct. 2007. ilus, graf
Article en En | LILACS | ID: lil-470214
Biblioteca responsable: BR1.1
ABSTRACT

INTRODUCTION:

Gleason score, which has a high interobserver variability, is used to classify prostate cancer. The most recent consensus valued the tertiary Gleason pattern and recommended its use in the final score of needle biopsies (modified Gleason score). This pattern is considered to be of high prognostic value in surgical specimens. This study emphasized the evaluation of the modified score agreement in needle biopsies and in surgical specimen, as well as the interobserver variability of this score MATERIALS AND

METHODS:

Three pathologists evaluated the slides of needle biopsies and surgical specimens of 110 patients, reporting primary, secondary and tertiary Gleason patterns and after that, traditional and modified Gleason scores were calculated. Kappa test (K) assessed the interobserver agreement and the agreement between the traditional and modified scores of the biopsy and of the surgical specimen

RESULTS:

Interobserver agreement in the biopsy was K = 0.36 and K = 0.35, and in the surgical specimen it was K = 0.46 and K = 0.36, for the traditional and modified scores, respectively. The tertiary Gleason grade was found in 8 percent, 0 percent and 2 percent of the biopsies and in 8 percent, 0 percent and 13 percent of the surgical specimens, according to observers 1, 2 and 3, respectively. When evaluating the agreement of the traditional and modified Gleason scores in needle biopsy with both scores of the surgical specimen, a similar agreement was found through Kappa

CONCLUSION:

Contrary to what was expected, the modified Gleason score was not superior in the agreement between the biopsy score and the specimen, or in interobserver reproducibility, in this study.
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Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Próstata / Neoplasias de la Próstata / Estadificación de Neoplasias Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Adult / Aged / Humans / Male Idioma: En Revista: Int. braz. j. urol Asunto de la revista: UROLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Brasil
Texto completo: 1 Colección: 01-internacional Base de datos: LILACS Asunto principal: Próstata / Neoplasias de la Próstata / Estadificación de Neoplasias Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Adult / Aged / Humans / Male Idioma: En Revista: Int. braz. j. urol Asunto de la revista: UROLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Brasil