Tratamiento con insulina aspártica bifásica en pacientes con diabetes en mal control metabólico: Experiencia clínica programada / Biphasic insulin aspart for the management of diabetic patients with unsatisfactory metabolic control
Rev. méd. Chile
; 135(10): 1253-1260, oct. 2007. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-470701
Biblioteca responsable:
BR1.1
ABSTRACT
Background: Biophasic insulin aspart (InAsBi) is a mixture of 30 percent of rapid acting soluble aspart insulin and 70 percent aspart insulin retarded with protamine. The soluble portion reduces postprandial serum glucose rises and the retarded portion reduces basal glucose levels. Aim: To assess the efficacy of biphasic insulin aspart in diabetics with a bad metabolic control. Material and methods: Multicentríc study that included diabetic patients with a glycosilated hemoglobin over 7 percent that were transferred to treatment with InAsBi, given in one to three daily doses, according to glycemic control and followed for 12 weeks. At the end of follow up, glycosilated hemoglobin levels (HbA1c) were measured again. Results: One hundred ninety six patients were enrolled and 154, age 59± 12 (84 females), completed the follow up. HbA 1 c levels decreased in at íeast 1 percent in 96 and increased in eight cases. In the total group HbA1c decreased from 10.1± 1.7 to 8.4±1.4 percent (p <0.01). Those with higher initial values and with oral therapy, had the greatest reductions. At the end of the observation period, 29 patients received one daily dose of InAsBi, 114 two doses and 11 three doses. Two patients had allergy, one systemic and one in the injection site. Conclusions: In this group of diabetic patients with a bad metabolic control, the use of InAsBi was associated with a significant reduction of glycosilated hemoglobin levels.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
ODS3 - Salud y Bienestar
Problema de salud:
Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles
Base de datos:
LILACS
Asunto principal:
Hemoglobina Glucada
/
Diabetes Mellitus Tipo 1
/
Hipoglucemiantes
/
Insulina
Tipo de estudio:
Ensayo clínico controlado
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2007
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL