Focal adhesion kinase signaling in cardiac hypertrophy and failure
Braz. j. med. biol. res
; 42(1): 44-52, Jan. 2009. ilus
Article
en En
| LILACS
| ID: lil-505421
Biblioteca responsable:
BR1.1
ABSTRACT
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Cardiomegalia
/
Miocitos Cardíacos
/
Proteína-Tirosina Quinasas de Adhesión Focal
/
Fibroblastos
/
Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2009
Tipo del documento:
Article
/
Congress and conference
/
Project document
País de afiliación:
Brasil
Pais de publicación:
Brasil