Cardiac and pulmonary alterations in symptomatic and asymptomatic dogs infectednaturally with Leishmania (Leishmania) chagasi
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;43(3): 310-315, Mar. 2010. ilus, tab
Article
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| ID: lil-539718
Biblioteca responsable:
BR1.1
ABSTRACT
Fifteen symptomatic and seven asymptomatic dogs infected naturally with Leishmania chagasi were examined in order to identify the presence of parasites and changes in heart and lung. Histopathological, cytological, and immunohistochemical analyses were performed on samples of heart and lung tissues. An inflammatory reaction characterized by inflammatory mononuclear, perivascular and intermuscular infiltrates was observed in both symptomatic and asymptomatic animals on histopathological analysis of the heart. In the lung, there was thickening of the alveolar septa due to congestion, edema, inflammatory infiltrate, and fibroblast proliferation. A focal reaction was observed although a diffuse reaction was present in both groups. On cytological examination, heart and lung imprints revealed amastigotes in two symptomatic animals and heart imprints were found in 1 asymptomatic dog. Immunoperoxidase staining showed amastigotes in the lung and heart of only 1 of 6 symptomatic animals examined. Within the ethical principles and limits of this research, it can be inferred that the study of heart and lung alterations in canine visceral leishmaniasis is increasingly important for understanding the problem related to humans. Dogs with visceral leishmaniasis were a good experimental model, since infection was caused by the same agent and the animals developed clinical, pathological and immunological alterations similar to those observed in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Leishmania infantum
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Enfermedades de los Perros
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Leishmaniasis Visceral
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Pulmón
/
Miocardio
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Aspecto:
Ethics
Límite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
/
Braz. j. med. biol. res
/
Braz. j. med. biol. res. (Online)
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Brazilian journal of medical and biological research
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Brazilian journal of medical and biological research (Impresso)
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Rev. bras. pesqui. méd. biol
/
Revista brasileira de pesquisas médicas e biológicas
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil