Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
Acta cir. bras
; 28(1): 48-54, jan. 2013. ilus, tab
Article
en En
| LILACS
| ID: lil-662347
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading.METHODS:
We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading.RESULTS:
KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657).CONCLUSION:
KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Astrocitoma
/
Neoplasias Supratentoriales
/
Biomarcadores de Tumor
/
Proteínas Proto-Oncogénicas c-kit
/
Factor A de Crecimiento Endotelial Vascular
/
Neovascularización Patológica
Tipo de estudio:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil