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Diagnostic challenges of single plaque-like lesion paucibacillary leprosy
Mem. Inst. Oswaldo Cruz ; 109(7): 944-947, 11/2014. tab, graf
Artículo en Inglés | LILACS | ID: lil-728804
Biblioteca responsable: BR1.1
ABSTRACT
The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: LILACS Asunto principal: Piel / ADN Bacteriano / Lepra Paucibacilar / Mycobacterium leprae Aspecto clínico: Diagnóstico Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2014 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Instituto Oswaldo Cruz-Fiocruz/BR