Reduced phagocytic a activity mediated by C3b and Fc monocyte receptors from children with sckle-cell disease
Braz. j. med. biol. res
; 22(6): 725-8, June 1989. tab
Article
en En
| LILACS
| ID: lil-75197
Biblioteca responsable:
BR26.1
RESUMO
The causes of high morbidity due to infection among children with sickle-cell disease (SD) are unknown. Immunlogical studies have focused on spleen function, on the alternative complement pathway, and recently on phagocytic activity. We evaluated Fc recptor-mediated phagocytic activity. We evaluated Fc receptor-mediated phagocytosis (sheep red cells opsonized with rabbit anti-E IgG, EA) and C3b receptor-mediated phagocytosis (zymosan particles incubated with fresh serum) in 27 children with SD. The control group consisted of 28 normal children matched by age and sex. The phagocytic indices obtained for cells from patients with SD were significantly lower than those for the controls (P < 0.001), both when EA and zymosan were used independent of whether the zymosan particles were incubated with patient serum or with a pool of normal sera. The results suggest the absence of abnormalities in the alternative complement pathway but do indicate an intrinsic cellular defect
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Fagocitosis
/
Monocitos
/
Receptores de Complemento
/
Receptores Fc
/
Anemia de Células Falciformes
Límite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Brasil