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Terapía combinada de propranolol y diltiazem en angina crónica de esfuerzo / Combined therapy with propranolol and diltiazem in with chronic exertional angina
Rev. méd. Chile ; 118(8): 889-94, ago. 1990. ilus
Article en Es | LILACS | ID: lil-96558
Biblioteca responsable: CL1.1
ABSTRACT
The effects of diltiazem, 240 mg/day, were studied in 12 p atients with chronic exertional angina and angiographically proven coronary artery disease, who received maintenance therapy with propranolol. Mean age was 60,1 years (range 46 to 67). Patients received propranolol, 60 to 240 mg/day, before and during the study. A double blind, placebo contorlled, cross-over design was used to test the effect of added diltiazem, durign 8 weeks. Duration fo execise varied from 398 ñ 30 (mean ñ SEM) to 419 ñ 37 (placebo) or 469 ñ 35 sec (diltiazem) (NS). Time to appearance of angina veried from 283 ñ 32 to 313 ñ 34 and 302 - 27 sec, respectively (NS). Resting and maximal effort heart rate and blood pressure did not differ among basal, placebo and iltiazem conditions. Segmental wall motion analysis by radioisotopic ventriculogram revealed diskynetic zones during placebo rodiltiazem therapy. Basal ejection fraction did not increase during exercise and this was not modified by diltiazem or placebo. Thus, the addition of diltiazem to propanolol in patients with chronic, exertional angina failed to modify angina threshold, exercise duration or left ventricular performance
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Propranolol / Diltiazem / Angina de Pecho Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 1990 Tipo del documento: Article Pais de publicación: Chile
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Colección: 01-internacional Base de datos: LILACS Asunto principal: Propranolol / Diltiazem / Angina de Pecho Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: Es Revista: Rev. méd. Chile Asunto de la revista: MEDICINA Año: 1990 Tipo del documento: Article Pais de publicación: Chile