Effects of undernutrition during suckling on ATP and ADP hydrolysis by synaptosomes from the cerebral cortex of adult rats
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;24(5): 515-26, 1991. tab
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ABSTRACT
Early undernutrition can cause permanent functional changes in the nervous system. Alterations in enzymes involved in neurotransmiter metabolism have been reported to result from early undernutrition. In a previous study, we demonstrated that undernutrition during suckling decreaseATP and ADP hydrolysis by synaptosomes from cerebral cortex by abouth 20% of the value found in 20-day-old well-nourished rats (j.B.T. Rocha, C.F. Melo, J.J.F.Sarkis and R.D. Dias, British Journal of Nutrition, 63273-283, 1990). In the present study, we investigated whether this deficit persists in synaptosomes from cerebral cortex of nutritionally rehabilitated adult rats. rats were undernourished from birth to 25 days of life by feeding their dams a 7% casein (w/w) diet, while well-nourished offspring were fed by mothers maintained on a 28% casein diet. In contrast to the results previously obtained in young rats, the synaptosomes obtained from the cerebral cortex of early undernourished adult rats hydrolyzed ATP and ADP more efficiently than did those obtained from well-nourished rats. Specific activity (nmol min-1 mg protein-1, mean ñ SD) was 114.9ñ9.5 for undernourished rats (N=8) for ATP, and 50.4ñ6.1 (N=8) vs 38.8ñ4.5 (N=8) for ADP. These results suggest that the deficits found in young rats disappear in rehabilitation adult rats
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Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Sinaptosomas
/
Adenosina Difosfato
/
Corteza Cerebral
/
Adenosina Trifosfato
/
Desnutrición Proteico-Calórica
Límite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
/
Braz. j. med. biol. res
/
Braz. j. med. biol. res. (Online)
/
Brazilian journal of medical and biological research
/
Brazilian journal of medical and biological research (Impresso)
/
Rev. bras. pesqui. méd. biol
/
Revista brasileira de pesquisas médicas e biológicas
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Brasil