Effects on body weight of strict or liberal adherence to an initial period of VLCD treatment. A randomised, one-year clinical trial of obese subjects.
Int J Obes Relat Metab Disord
; 23(2): 190-7, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-10078855
ABSTRACT
OBJECTIVES:
To examine the impact on early and late weight loss of three different, initial very low calorie diet (VLCD) approaches in a one-year obesity treatment program.DESIGN:
Randomised clinical trial.SUBJECTS:
121 obese subjects, aged 21-60y, BMI > or = 30.0kg/m2.INTERVENTIONS:
The VLCD-strict group was prescribed a strict outpatient VLCD for 16 weeks, followed by a 36-week hypocaloric diet. The VLCD-mw group received the same treatment, but were hospitalised in a metabolic ward for the initial week. The VLCD-plus group was allowed two small meals weekly, but received otherwise the same recommendations as the VLCD-strict group.RESULTS:
After 16 weeks, there was no difference in weight loss between the treatment groups in the intent-to-treat population, while among completers, the weight loss was about 7 kg larger in the VLCD-strict group compared to the VLCD-plus group (P < 0.05). At one year, these groups differed by approximately 4 kg, both according to intention-to-treat and among completers (P < 0.05, both differences). These differences were more prominent among females. The weight reduction in the VLCD-mw group was generally not superior to the VLCD-strict group.CONCLUSIONS:
In the short-term, strict VLCD only reduced weight better than a liberal VLCD approach among completers. However, after one year, a strict VLCD regimen seemed beneficial compared to a liberal VLCD for all patients. There was no extra weight loss if the VLCD period was initiated on a metabolic ward.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cooperación del Paciente
/
Dieta Reductora
/
Hospitalización
/
Obesidad
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Guideline
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Int J Obes Relat Metab Disord
Año:
1999
Tipo del documento:
Article
País de afiliación:
Suecia