Expression of CD80 and CD86 on peripheral blood T lymphocytes in patients with systemic lupus erythematosus.
J Clin Immunol
; 19(1): 58-66, 1999 Jan.
Article
en En
| MEDLINE
| ID: mdl-10080105
ABSTRACT
CD80 and CD86 were detected in high amounts on circulating T cells in the peripheral blood of some patients with systemic lupus erythematosus (SLE), using flow cytometry and monoclonal antibodies. Patients with other connective tissue diseases did not have a high percentage of T cells expressing CD80 or CD86 in their peripheral blood. CD80 was expressed mainly on CD4 T cells, whereas CD86 was expressed on CD8 T cells, and these two populations were associated with particular clinical features. These two molecules were expressed on different T-cell populations and might have different roles in the generation and regulation of immune responses. Since high expression of CD86 on T cells was detected much earlier than the appearance of clinical features and a high titer of anti-DNA antibody, it may be a useful parameter for predicting the flare of SLE.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Antígenos CD
/
Antígeno B7-1
/
Lupus Eritematoso Sistémico
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Immunol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón