The folding funnel landscape for the peptide Met-enkephalin.
Proteins
; 34(4): 472-83, 1999 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-10081960
ABSTRACT
We study the free energy landscape of the small peptide Met-enkephalin. Our data were obtained from a generalized-ensemble Monte Carlo simulation taking the interactions among all atoms into account. We show that the free energy landscape resembles that of a funnel, indicating that this peptide is a good folder. Our work demonstrates that the energy landscape picture and folding concept, developed in the context of simplified protein models, can also be used to describe the folding in more realistic models.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalina Metionina
Tipo de estudio:
Health_economic_evaluation
Idioma:
En
Revista:
Proteins
Asunto de la revista:
BIOQUIMICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos