The complete sequence and expression patterns of the atrial myosin heavy chain in the developing chick.
Biol Cell
; 90(9): 605-13, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-10085537
ABSTRACT
We have earlier reported partial cloning of a cDNA of a chick atrial myosin heavy chain (MHC) gene, CCSV2 and its expression pattern in embryonic chick hearts (Oana et al (1995) Eur J Cell Biol 67, 42-49). In this study, five overlapping cDNA clones (including CCSV2) which together encode the entire open reading frame of the chick atrial MHC gene were characterized, and both the entire nucleotide sequence consisting of 5825 bases and the deduced amino acid sequence consisting of 1931 amino acids determined. Reinvestigation of the nucleotide sequence of the previously reported and presumably different chick atrial specific MHC cDNA clone, AMHC1 (Yutzey et al (1994) Development 120, 871-883), revealed that our clone and AMHC1 encoded the same MHC. The chick atrial MHC gene was strongly expressed in developing chick atria from a very early stage (Hamburger and Hamilton stage 9, 29-33 h) to the adult stage. This gene was also expressed, although weakly, in the ventricle, somite (the precursor to skeletal muscle) and skeletal muscle during embryonic stages but not in adults.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cadenas Pesadas de Miosina
/
Atrios Cardíacos
Límite:
Animals
Idioma:
En
Revista:
Biol Cell
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón