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Acute metabolic effects of human growth hormone on 15N-nitrogen balance in patients with thalassaemia as compared to patients with other types of short stature.
Zachmann, M; Kempken, B; De Sanctis, V.
Afiliación
  • Zachmann M; Department of Paediatrics, Universities of Zurich, Switzerland.
J Pediatr Endocrinol Metab ; 11 Suppl 3: 851-6, 1998.
Article en En | MEDLINE | ID: mdl-10091156
ABSTRACT
The acute response to various doses of human growth hormone (hGH) was determined in short patients with thalassaemia and compared to that in patients with classic growth hormone deficiency and Turner's syndrome. Nitrogen balance was analyzed using the stable isotope 15N. While patients with growth hormone deficiency responded with a marked nitrogen retention (+2.9 +/- 0.4 to +6.1 +/- 0.6 mg 15N/kg) to small doses of hGH (2 x 3 IU/m2), those with Turner's syndrome had a higher basal balance, but responded much less (+3.1 +/- 0.7 to +3.7 +/- 1.8 mg 15N/kg). They required a double dose of hGH (2 x 6 IU/m2) to achieve a significant retention (+4.1 +/- 1.0 to +7.1 +/- 0.4 mg 15N/kg). The thalassaemic patients responded still less than the patients with Turner's syndrome to 2 x 6 IU/m2 (+7.7 +/- 0.3 to +8.0 +/- 0.4 mg 15N/kg), and even hGH doses up to 2 x 12 IU/m2 had little effect, indicating a relative resistance to hGH. In conclusion, no or little effect is to be expected from long-term hGH treatment at low doses in thalassaemic patients. When it is decided to treat these patients, the dose should be about 4 times higher than a regular replacement dose in growth hormone deficiency.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Talasemia beta / Hormona de Crecimiento Humana / Trastornos del Crecimiento / Nitrógeno Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Pediatr Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / PEDIATRIA Año: 1998 Tipo del documento: Article País de afiliación: Suiza
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Talasemia beta / Hormona de Crecimiento Humana / Trastornos del Crecimiento / Nitrógeno Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Pediatr Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / PEDIATRIA Año: 1998 Tipo del documento: Article País de afiliación: Suiza