Solid-phase synthesis of novel inhibitors of farnesyl transferase.
Bioorg Med Chem Lett
; 9(4): 623-6, 1999 Feb 22.
Article
en En
| MEDLINE
| ID: mdl-10098677
ABSTRACT
A novel diphosphate mimic, the 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy group (1), has been employed as the template in the solid-phase synthesis of novel farnesyl transferase inhibitors using the Mitsunobu reaction. The most potent inhibitor (farnesyloxy-5-hydroxy-2,3,6-trifluoro-4-nitrobenzene) displayed an IC50 of 6.3 microM versus farnesyl transferase.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transferasas Alquil y Aril
/
Inhibidores Enzimáticos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Reino Unido