Effectiveness and economic impact of antidepressant medications: a review.
Am J Manag Care
; 3(2): 323-30; quiz 331, 1997 Feb.
Article
en En
| MEDLINE
| ID: mdl-10169266
ABSTRACT
This article reviews the existing literature on the pharmacoeconomics and effectiveness of antidepressant medications. Although selective serotonin reuptake inhibitors (SSRIs) have not proved to be more efficacious than the older tricyclics, and their prescription costs are significantly higher, they provide superior effectiveness; ie, patients are less likely to discontinue taking them or switch antidepressants. Pharmacoeconomic studies consistently demonstrate a relationship between this superior effectiveness and reductions in overall treatment costs, often through decreased utilization of medical and hospital services. The most conservative study found a cost offset that more than negated the extra cost of drugs, although the cost savings were not statistically significant. Other studies found statistically significant lowering of utilization costs by using SSRIs rather than tricyclics. Studies comparing SSRIs with each other present conflicting findings, although fluoxetine appears to have an edge over sertraline and paroxetine with regards to effectiveness and pharmacoeconomics. More studies employing a prospective outcome design and naturalistic study setting need to be conducted with SSRIs and other new antidepressants.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Economía Farmacéutica
/
Antidepresivos de Segunda Generación
/
Depresión
/
Antidepresivos Tricíclicos
Tipo de estudio:
Health_economic_evaluation
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Manag Care
Asunto de la revista:
SERVICOS DE SAUDE
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos