Effects of some beta-carboline alkaloids on intact Trypanosoma cruzi epimastigotes.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 122(1): 27-31, 1999 Jan.
Article
en En
| MEDLINE
| ID: mdl-10190025
Several beta-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuén and LQ) showing different sensitivity to nifurtimox. Important differences were observed in the susceptibility of the parasites to these natural substances, with the relatively nifurtimox-resistant LQ strain showing greater sensitivity to the beta-carbolines. Respiratory chain inhibition appears to be a possible determinant of the trypanosomicidal activity of these compounds.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tripanocidas
/
Trypanosoma cruzi
/
Carbolinas
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Estados Unidos