D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease.
Intensive Care Med
; 25(2): 207-10, 1999 Feb.
Article
en En
| MEDLINE
| ID: mdl-10193549
ABSTRACT
OBJECTIVE:
To determine if D-dimer predicts outcomes in critically ill patients.DESIGN:
Observational, cohort study.SETTING:
Medical intensive care unit (MICU) of a tertiary care hospital. PATIENTS ANDPARTICIPANTS:
Seventy-four patients consecutively admitted to the MICU.INTERVENTIONS:
D-dimer was measured by latex agglutination within 12 h of admission to the MICU. MEASUREMENTS ANDRESULTS:
Of the study population, 43.2% had positive D-dimers. The in-hospital mortality rate in D-dimer positive patients was 28.1% as compared to 7.1% in D-dimer negative subjects (p = 0.024). D-dimer positive patients had significantly greater frequencies of venous thromboses (21.9% vs 4.8%, p = 0.035).CONCLUSIONS:
The D-dimer assay identifies patients at increased risk for mortality and may be a more sensitive test to determine the presence of underlying microvascular pathology in critically ill patients. A positive D-dimer at admission to the MICU is associated with an increased risk for the later development of a venous thromboembolic event (VTE).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Productos de Degradación de Fibrina-Fibrinógeno
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Intensive Care Med
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos