[The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic myelosuppression]. / Gemostimuliruiushchie svoistva rekombinantnogo koloniestimuliruiushchego faktora i glitsirama v usloviiakh tsitostaticheskoi mielosupressii.

ABSTRACT

The hemostimulating activity of the drug glycyrram and the recombinant granulocytic-macrophagic colony-stimulating factor (CSF) was compared on models of myelosuppression induced by injection of an alkylating agent cyclophospane (CF) or the antimetabolite 5-fluorouracil (5-FU). It was found that glycerram stimulated hematopoiesis more effectively after 5-FU injection but to a lesser extent (in relation to CSF) in CF injection.