Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting.
Acta Neurol Belg
; 99(1): 65-9, 1999 Mar.
Article
en En
| MEDLINE
| ID: mdl-10218096
ABSTRACT
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by autoreactive T cells with specificity for myelin antigens. The identity of the brain antigens, which are the primary targets of the autoimmune process remains unknown, but myelin basic protein (MBP) is a likely candidate. We will overview some of the experimental evidence, suggesting that MBP reactive T cells hold a central position in the pathogenesis of MS, and discuss how these autoreactive T cells can be therapeutically targeted by T cell vaccination.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Autoinmunidad
/
Inmunoterapia
/
Esclerosis Múltiple
Límite:
Humans
Idioma:
En
Revista:
Acta Neurol Belg
Año:
1999
Tipo del documento:
Article
País de afiliación:
Bélgica