A comparative study on the effect of felodipine and propranolol on serum lipid profile of rabbits.
Indian J Physiol Pharmacol
; 41(3): 269-74, 1997 Jul.
Article
en En
| MEDLINE
| ID: mdl-10232772
ABSTRACT
Effect of felodipine on serum lipids of rabbits was studied and was compared with that of propranolol. Lipid parameters were estimated at basal (0 wk), end of 4th and 16th week of diet/drug administration by using standard kits for analysis. There was a significant increase in mean serum cholesterol, TG, VLDLc, LDLC and decrease in HDLc, (P<0.05) in the group of rabbits receiving Atherogenic diet (AD)/Propranolol. This effect was maximally observed in rabbits receiving both AD and propranolol. This change was satisfactorily prevented when felodipine was administered from very beginning (P<0.001). In addition, there was a significant increase in HDLc (28.89%) of rabbits receiving felodipine from beginning. Thus both AD and propranolol have dyslipidemic effect and early administration of felodipine favorably changes all lipid parameters.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propranolol
/
Bloqueadores de los Canales de Calcio
/
Felodipino
/
Lípidos
/
Hipolipemiantes
Límite:
Animals
Idioma:
En
Revista:
Indian J Physiol Pharmacol
Año:
1997
Tipo del documento:
Article