Matrilysin as a target for chemotherapy for colon cancer: use of antisense oligonucleotides as antimetastatic agents.
Cancer Chemother Pharmacol
; 43 Suppl: S52-5, 1999.
Article
en En
| MEDLINE
| ID: mdl-10357559
ABSTRACT
Matrilysin (MMP-7) is the smallest member of the matrix metalloproteinase (MMP) family. It is frequently expressed in various types of cancer including colon, stomach, prostate, and brain cancers. Previous studies have suggested that matrilysin plays important roles in the progression and metastasis of colon cancer. Recently, we have examined the effects of a matrilysin-specific antisense phosphorothioate oligodeoxyribonucleotide on in vitro invasion and liver metastasis in nude mice of two human colon carcinoma cell lines (CaR-1 and WiDr). In culture, the antisense oligonucleotide effectively inhibited both the secretion of matrilysin by CaR-1 cells and their in vitro invasion through a reconstituted basement membrane. In a nude mouse model, the antisense oligonucleotide potently suppressed the experimental liver metastasis of WiDr cells from the spleen. These results suggest that matrilysin has an important role in the liver metastasis of human colon cancer and that matrilysin antisense oligonucleotides have therapeutic potential for the prevention of metastasis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metaloendopeptidasas
/
Oligonucleótidos Antisentido
/
Neoplasias del Colon
/
Metástasis de la Neoplasia
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Japón