[Formation of two types of a proteolytically cleaved nucleoprotein in cells, infected by influenza virus]. / Formirovanie dvukh tipov proteoliticheski rasshcheplennogo nukleoproteina v kletkakh, zarazhennykh virusom grippa.
Vopr Virusol
; 44(2): 65-9, 1999.
Article
en Ru
| MEDLINE
| ID: mdl-10358899
ABSTRACT
Two types of proteolytically cleaved influenza virus nucleoprotein (NP) are formed in cells infected with influenza virus. One, cell membrane-associated cleaved NP (C-NP), is heterogeneous in size and during analysis in PAGE is localized in the 53 kDa and less zone. Its formation depends on the species appurtenance of the infective virus and occurs only in viruses with a low efficacy of NP oligomerization. C-NP is incapable of intracellular oligomerization. The other type of cleaved NP, extracellular free (F-NP), is most likely a secreted product of intracellular proteolysis of 56 kDa NP. Its molecular weight is about 53 kDa. Its formation does not depend on the species of infective influenza virus and it is capable of intracellular oligomerization.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Proteínas del Núcleo Viral
/
Proteínas de Unión al ARN
/
Nucleoproteínas
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Virusol
Año:
1999
Tipo del documento:
Article